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. Author manuscript; available in PMC: 2021 Jan 16.
Published in final edited form as: Vaccine. 2019 Nov 4;38(3):620–626. doi: 10.1016/j.vaccine.2019.10.051

Figure 1: Survival following vaccination with GP-recombinant proteins in BALB/c mice.

Figure 1:

Mice received 3 vaccinations with the indicated recombinant protein followed by an orotracheal challenge with 2×104 CFU of C. neoformans strain KN99. Mice were then assessed for survival over the next 84 days. Protective proteins are listed in bold. (A) Each dot represents one mouse, and the bars denote the geometric mean survival. Experimental groups are depicted as solid black circles with red bars. Unvaccinated and GP-MSA vaccinated controls are shown as hollow circles with black bars. (B) Descriptive statistics of candidate GP-vaccines. n = number of mice in the group. # mice 84 DPI indicates the number of survivors at d84 when the study ended. Geometric mean (DPI) refers to geometric mean survival in DPI. P values were calculated by Kaplan-Meier survival with Mantel-Cox significance compared to GP-MSA vaccinated mice. After applying the Bonferroni correction, significant comparisons (P<0.0023) are denoted in italics.