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. Author manuscript; available in PMC: 2021 Jan 16.
Published in final edited form as: Vaccine. 2019 Nov 4;38(3):620–626. doi: 10.1016/j.vaccine.2019.10.051

Figure 3: Criteria for selection of extracellular protein antigens.

Figure 3:

Initial selection of candidate antigens was based on transcript abundance (●), presence in alkaline extracts (▲), and/or known immunogenicity (■). Each method of selection yielded both protective (red) and non-protective (black) vaccines. Dotted lines indicate the cutoff for the top 500 most abundant transcripts, wherein a rank of “1” represents the highest number of transcripts. Transcriptome data from YPD-cultured Cryptococcus are graphed against those obtained from human CSF [18].