Table 5.
Sensitivity analyses for the association between ADHD medication and unintentional injuries
| N of individuals | N of events | Within-individual OR (95% CI) | |
|---|---|---|---|
| All unintentional injuries | |||
| Male | |||
| Incident diagnosis cohort | 309 719 | 17 168 | 0.77 (0.74–0.81) |
| Incident diagnosis cohort and first event only | 309 719 | 14 656 | 0.59 (0.56–0.63) |
| Cohort excluding the last month before disenrollment | 1 293 717 | 73 364 | 0.72 (0.70–0.73) |
| Full cohort with index year in 2005–2008 | 336 132 | 22 012 | 0.76 (0.74–0.79) |
| Full cohort with index year in 2009–2014 | 996 916 | 53 834 | 0.70 (0.69–0.72) |
| Full cohort with one-month-extended medication periods | 1 333 048 | 75 936 | 0.71 (0.70–0.73) |
| Full cohort without short prescriptions | 1 234 590 | 60 374 | 0.84 (0.82–0.86) |
| Full cohort with stimulant medication as exposure only | 1 333 048 | 75 936 | 0.72 (0.70–0.73) |
| With no other psychotropic medication | 886 343 | 42 803 | 0.67 (0.65–0.69) |
| With no psychotherapy | 911 081 | 44 067 | 0.68 (0.66–0.70) |
| Full cohort with SSRIs as exposure | 1 333 048 | 75 936 | 1.17 (1.12–1.23) |
| Female | |||
| Incident diagnosis cohort | 162 727 | 6 562 | 0.79 (0.73–0.86) |
| Incident diagnosis cohort and first event only | 162 727 | 5 680 | 0.59 (0.53–0.64) |
| Cohort excluding the last month before disenrollment | 615 890 | 25 288 | 0.72 (0.69–0.75) |
| Full cohort with index year in 2005–2008 | 144 879 | 6 512 | 0.75 (0.70–0.81) |
| Full cohort with index year in 2009–2014 | 490 219 | 19 753 | 0.71 (0.68–0.74) |
| Full cohort with one-month-extended medication periods | 635 098 | 26 265 | 0.71 (0.68–0.74) |
| Full cohort without short prescriptions | 583 416 | 21 102 | 0.84 (0.81–0.87) |
| Full cohort with stimulant medication as exposure only | 635 098 | 26 265 | 0.72 (0.69–0.74) |
| With no other psychotropic medication | 383 010 | 12 444 | 0.68 (0.65–0.72) |
| With no psychotherapy | 407 850 | 13 652 | 0.68 (0.65–0.72) |
| Full cohort with SSRIs as exposure | 635 098 | 26 265 | 1.09 (1.02–1.16) |
| Unintentional TBI | |||
| Male | |||
| Incident diagnosis cohort | 309 719 | 2 174 | 0.86 (0.75–0.98) |
| Incident diagnosis cohort and first event only | 309 719 | 2 107 | 0.70 (0.61–0.81) |
| Cohort excluding the last month before disenrollment | 1 290 747 | 8 042 | 0.63 (0.59–0.68) |
| Full cohort with index year in 2005–2008 | 336 132 | 1 477 | 0.58 (0.50–0.67) |
| Full cohort with index year in 2009–2014 | 996 916 | 6 927 | 0.65(0.61–0.70) |
| Full cohort with one-month-extended medication periods | 1 333 048 | 8 404 | 0.61 (0.57–0.66) |
| Full cohort without short prescriptions | 1 234 590 | 7 589 | 0.63 (0.59–0.67) |
| Full cohort with stimulant medication as exposure only | 1 333 048 | 8 404 | 0.63 (0.59–0.67) |
| With no other psychotropic medication | 886 343 | 4 746 | 0.61 (0.56–0.67) |
| With no psychotherapy | 911 081 | 4 671 | 0.59 (0.54–0.64) |
| Full cohort with SSRIs as exposure | 1 333 048 | 8 404 | 1.41 (1.23–1.61) |
| Female | |||
| Incident diagnosis cohort | 162 727 | 736 | 0.79 (0.63–1.00) |
| Incident diagnosis cohort and first event only | 162 727 | 719 | 0.68 (0.52–0.87) |
| Cohort excluding the last month before disenrollment | 613 806 | 2 701 | 0.67 (0.60–0.75) |
| Full cohort with index year in 2005–2008 | 144 879 | 459 | 0.61 (0.47–0.79) |
| Full cohort with index year in 2009–2014 | 490 219 | 2 368 | 0.70 (0.62–0.79) |
| Full cohort with one-month-extended medication periods | 635 098 | 2 827 | 0.67 (0.60–0.75) |
| Full cohort without short prescriptions | 583 416 | 2 516 | 0.67 (0.60–0.75) |
| Full cohort with stimulant medication as exposure only | 635 098 | 2 827 | 0.70 (0.62–0.78) |
| With no other psychotropic medication | 383 010 | 1 225 | 0.72 (0.60–0.85) |
| With no psychotherapy | 407 850 | 1 337 | 0.71 (0.61–0.84) |
| Full cohort with SSRIs as exposure | 635 098 | 2 827 | 1.29 (1.08–1.54) |
Note: 95% CI= 95% confidence interval; OR= odds ratio; N= number; SSRIs= selective serotonin reuptake inhibitors; TBI= traumatic brain injury.