Figure 1. Two-hour treatment of whole porcine eye with 10 mM SMG in various 15cP HPMC concentrations.

Formulations containing different concentrations of 15cP HPMC (0, 1.1, 2.2, 4.4%) with 10 mM SMG were compared for their effect on cross-linking in cornea and sclera, after whole porcine globes were subjected to a 2-h incubation. Control tissue was prepared in an identical fashion but without SMG. ΔT_m represents the average shift in denaturation temperature to the control, after treatment. Cornea and sclera pieces were resected immediately after the incubation period. Asterisks (*) indicate significance (P < 0.05) based on non-paired test performed from three independent trials.