Figure 2. Two-hour treatment of whole rabbit eye with 10 mM SMG in various 15cP HPMC concentrations.

Formulations containing different concentrations of 15cP HPMC (0, 1.1, 2.2, 4.4%) with 10 mM SMG were compared for their effect on cross-linking in cornea and sclera, after enucleated rabbit eyes from ex vivo cadaveric rabbit head were subjected to a 2-h incubation. Control tissue was prepared in an identical fashion but without SMG. ΔT_m represents the average shift in denaturation after the incubation period. None of the groups reached statistical significance (P < 0.05) based on non-paired tests performed from three independent trials.