Table 2.

Off-target score of various ASO chemistries, lengths and combinations

	AK2	PROM1	RER1	CLIP4	UCK2	PTOV1	CSNK1G3
ASO1-MOE	1.8 (0.14)	1.5 (0.02)	1.5 (0.21)	1.6 (0.28)	0.7 (0.08)	0.0 (0.06)	1.1 (0.10)
ASO1-cEt/DNA	0.2 (0.04)	1.5 (0.20)	0.7 (0.16)	1.0 (0.13)	0.1 (0.0)	0.1 (0.01)	0.7 (0.10)
ASO2-MOE	2.2 (0.15)	2.2 (0.13)	1.4 (0.23)	1.5 (0.21)	1.3 (0.20)	1.2 (0.09)	1.2 (0.11)
ASO2-cEt/DNA	0.3 (0.06)	0.0 (0.0)	1.1 (0.20)	0.3 (0.06)	0.9 (0.09)	0.0 (0.01)	0.5 (0.12)
ASO1-MOE/DNA	0.0 (0.0)	1.0 (0.56)	0.3 (0.06)	1.5 (0.18)	0.0 (0.0)	0.2 (0.04)	1.0 (0.37)
12mer MOE	1.3 (0.16)	0.3 (0.01)	1.1 (0.14)	1.4 (0.13)	0.1 (0.01)	1.0 (0.09)	0.0 (0.02)
MOE combination	1.0 (0.06)	0.7 (0.18)	1.0 (0.09)	0.8 (0.05)	0.7 (0.06)	0.4 (0.02)	0.5 (0.05)

Data represent mean (SE) relative to PKM.