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. 2019 Nov 22;48(2):646–664. doi: 10.1093/nar/gkz1120

Figure 4.

Figure 4.

Defining the genomic binding sites and influences of MEF2D, HDAC4 and HDAC9 on H3K27ac. (A) Venn diagrams showing the overlaps between the MACS2-defined MEF2D, HDAC4 and HDAC9 ChIP-seq enriched peaks in SK-UT-1 cells. (B) Genomic distribution of the MACS2-defined MEF2D, HDAC4 and HDAC9 ChIP-seq enriched peaks in SK-UT-1 cells. (C) Proximity, expressed as percentage, of H3K27ac marks to the MEF2D, HDAC4 and HDAC9 ChIP-seq enriched peaks in SK-UT-1 cells. The minimum distance is 0bp (overlapping) and 1kbp, respectively, for the left and right panel. (D) Heatmaps showing the differences in H3K27ac distribution between HDAC4−/− and HDAC4+/+ or HDAC9−/− and HDAC9+/+ SK-UT-1 cells. The displayed regions are located ±3kb around the TSS of a subset of 475 microarray-defined HDAC4 repressed genes (left panel) and of 118 microarray-defined HDAC9 repressed genes (right panel). Binding peaks for MEF2D, HDAC4 and HDAC9 in the same regions are also provided. The differences in mRNAs levels are indicated by the heatmaps at the bottom.