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. 2019 Nov 28;48(2):934–948. doi: 10.1093/nar/gkz1104

Figure 3.

Figure 3.

Structural models and heptad wheel presentation of permissible complexes of MITF variant homodimers and heterodimers with bHLH-Zip transcription factors: (A) MITF2(wt), (B) MITF(Δ)2, (C) MITF(wt)/TFEB, (D) MITF(Δ)/MAX. Residue types in positions a/a’, d/d’, e/e’ and g/g’ of all visible heptad repeats are listed; for positions e/e’ and g/g’, in addition the residue numbers are given. To facilitate recognition of specific attractive interactions, acidic residues are in red, basic residues are in blue, and other hydrophilic residues are in pink. Those hydrogen bonds that are conserved in all four models are shown by solid lines with solid arrows; hydrogen bonds that are partly conserved are shown by solid lines with open arrows; non-conserved hydrogen bonds specific for one of the complexes illustrated are shown by dashed lines with open arrows. Additional color codes: TFEB, yellow; MAX, gray. The icon size for the different heptad positions differ to provide an intuitive impression of their location orthogonal to the document plane.