Table 2.
MITF-related HLH-bZip structures
| 4ATH - MITF(wt, apo) | 6G1L - MITF(wt, CLEAR) | 6FX5 (Δ, apo) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Query cover [%] | Sequence identity [%] | RMS [Å] | Query cover [%] | Sequence identity [%] | RMS [Å] | Query cover [%] | Sequence identity [%] | RMS [Å] | |
| Self-recognition | |||||||||
| 4ATH | 77.6 | 96.9 | 1.5 | 92.4 | 55.2 | 2.0 | |||
| 6G1L | 75.7 | 96.9 | 1.5 | 78.0 | 67.0 | 1.6 | |||
| 6FX5 | 83.4 | 55.2 | 2.0 | 72.0 | 67.0 | 1.6 | |||
| Related homodimer clusters | |||||||||
| MAX (1RO5) | 75.6 | 15.6 | 2.7 | 70.7 | 21.0 | 2.3 | 84.5 | 22.6 | 2.4 |
| MYC (5IAZ) | 69.5 | 24.2 | 2.2 | 66.2 | 25.9 | 2.3 | 81.8 | 22.6 | 2.7 |
| SREBP-1A (1AM9) | 67.7 | 34.7 | 2.0 | 85.6 | 36.4 | 1.7 | 75.1 | 33.6 | 1.8 |
| Related heterodimer clusters | |||||||||
| MYC/MAX (1NKP) | 71.4 | 20.9 | 2.8 | 77.3 | 26.8 | 1.9 | 82.9 | 21.4 | 2.0 |
| SCI/E47 (2YPB) | 56.8 | 25.3 | 2.0 | 75.7 | 26.2 | 1.7 | 58.6 | 28.6 | 1.8 |
| CLOCK/BMAL1 (4H1O) | 51.6 | 31.0 | 1.5 | 69.5 | 32.2 | 1.6 | 55.9 | 33.0 | 2.0 |
For further details, see Supplementary Table 2.