Table 3.
MITF (Δ) | MITF (wt) | ||
---|---|---|---|
M-box | K D [nM] | 1.3 ± 0.3 × 101 | 2.5 ± 0.5 |
Binding stoichiometry (n) | 0.499 ± 0.008 | 0.505 ± 0.010 | |
E-box | K D [nM] | 1.0 ± 0.1 × 101 | 1.7 ± 0.2 |
Binding stoichiometry (n) | 0.503 ± 0.006 | 0.492 ± 0.018 | |
Synthetic random | K D [nM] | 3.0 ± 0.6 × 102 | 4.9 ±0.4 × 102 |
Binding stoichiometry (n) | 0.464 ± 0.016 | 0.505 ± 0.04 | |
Selectivity | M-box / Synthetic random | 23 | 196 |
E-box / Synthetic random | 30 | 288 |