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. 2019 Dec 4;48(2):788–801. doi: 10.1093/nar/gkz1126

Figure 6.

Figure 6.

Model of Gemin5-p85 heterodimer driven by the TPR-like domain. (A) Schematic of Gemin5 dimer. The relative orientation between the WD40s, TPRs and RBS1/2 domains of Gemin5 is unknown, although they are represented at three different levels to highlight their distinct roles in snRNA and ribosome binding (WD40s), dimerization (TPR-like) and translation mRNA binding (RBS1/2). (B) Schematic representation of the association between Gemin5 (orange) and p85 (blueish). (C) Schematic representation of p85-A951E. The prohibition sign indicates that mutation A951E abrogates the interaction with Gemin5.