Skip to main content
. 2019 Aug 11;22(1):46–57. doi: 10.1093/neuonc/noz136

Fig. 4.

Fig. 4

NFAT2 regulates GSC growth in vivo. (A) H&E-stained brain sections of mice after intracranial transplantation of G08 GSCs transfected with shC, shNFAT2-1, or shNFAT2-2. Brains were harvested at 15 days after transplantation. NFAT2 silencing significantly inhibited tumor growth in vivo. Scale bars = 1 mm. (B) Kaplan–Meier survival curves of mice injected with G08 GSCs transfected with shC, shNFAT2-1, or shNFAT2-2. (C) IHC staining of NFAT2 and CD44 in intracranial tumors derived from G08 GSCs transfected with shC, shNFAT2-1, or shNFAT2-2. Scale bar = 25 μm. (D) H&E-stained brain sections of mice after intracranial transplantation of G12 GSCs transfected with the NFAT2 overexpression plasmids or empty vector. Brains were harvested at 15 days after transplantation. NFAT2 overexpression markedly enhanced tumor growth in vivo. Scale bars = 1 mm. (E) Kaplan–Meier survival curves of mice injected with G12 GSCs transfected with the NFAT2 overexpression plasmids or empty vector. (F) IHC staining of NFAT2 and CD44 in intracranial tumors derived from G12 GSCs transfected with the NFAT2 overexpression plasmids or empty vector. Scale bar = 25 μm. *P < 0.05, **P < 0.01.