90Y PET/CT liver phantom results. (A) Noise and activity recovery at 1, 2, and 3 iterations (21 subsets) of 3-dimensional ordered-subset expectation maximization with time of flight, resolution recovery, and with and without 5-mm gaussian postprocessing filter. (B) Coronal slice at different iterations. (C) PET/CT corresponding to reconstruction parameters selected for patient study (1 iteration, 21 subsets with filtering).