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. 2019 Dec 30;2019:3815952. doi: 10.1155/2019/3815952

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Copyright © 2019 Jia Tang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Construction of the OS/RFS miRNA signatures. Tuning parameter (λ) selection crossvalidation error curve for OS/RFS-relevant miRNA. The vertical lines were drawn at the optimal values by the minimum criteria and the 1-SE criteria (a, d). The LASSO coefficient profiles of 17 overall survival-related miRNAs; the vertical line is drawn at the value chosen by 10-fold crossvalidation (b). The LASSO coefficient profiles of 13 recurrence-free survival-related miRNAs; the vertical line is drawn at the value chosen by 10-fold crossvalidation (e). Hazard ratio of the enrolled OS-related miRNAs (c) and enrolled RFS-related miRNAs (f). LASSO coefficient profiles of OS-relevant miRNAs associated with the prognosis of patients with breast cancer (a–c); LASSO coefficient profiles of RFS-relevant miRNAs associated with the prognosis of patients with breast cancer (d–f).