Table 2.
Correlation Analyses of MT, IN, and ID Biomarkers in 45 Patients During the Course of CDI
| LBP T0 | EndoCab IgM T0 | IL-6 T0 | I-FABP T0 | LBP T1 | EndoCab IgM T1 | IL-6 T1 | I-FABP T1 | CRP | CRE | |
|---|---|---|---|---|---|---|---|---|---|---|
| LBP T0 | – | –0.23 0.11 | 0.52 0.0002 | 0.0128 0.9392 | 0.42 0.004 | –0.18 0.22 | 0.12 0.43 | 0.10 0.54 | 0.18 0.25 | –0.30 0.05 |
| EndoCab IgM T0 | – | – | –0.38 0.01 | 0.06 0.71 | –0.15 0.32 | 0.82 <0.0001 | –0.13 0.39 | 0.02 0.86 | –0.04 0.77 | 0.17 0.28 |
| IL-6 T0 | – | – | – | –0.05 0.75 | 0.13 0.37 | –0.40 0.006 | 0.28 0.06 | 0.04 0.8 | –0.02 0.9 | |
| I-FABP T0 | – | – | – | – | 0.12 0.45 | –0.17 0.29 | –0.04 0.77 | 0.71 <0.0001 | 0.04 0.8 | –0.30 0.09 |
| LBP T1 | – | – | – | – | – | 0.07 0.63 | 0.60 <0.0001 | –0.06 0.70 | 0.02 0.89 | 0.03 0.85 |
| EndoCab IgM T1 | – | – | – | – | – | – | –0.19 0.20 | –0.21 0.21 | –0.08 0.6 | 0.15 0.35 |
| IL-6 T1 | – | – | – | – | – | – | – | –0.08 0.61 | 0.03 0.84 | –0.10 0.54 |
| I-FABP T1 | – | – | – | – | – | – | – | – | 0.10 0.58 | –0.31 0.09 |
The first lines are Spearman correlation coefficient values; the second lines are P values. Values in bold represent statistically significant correlations (P < .05).
Abbreviations: CDI, Clostridioides difficile infection; CRE, creatinine; CRP, C-reactive protein; EndoCab IgM, antiendotoxin core antibody IgM; I-FABP, intestinal fatty acid binding protein; ID, intestinal damage; IN, inflammation; LBP, lipopolysaccharide-binding protein; MT, microbial translocation; T0, at the beginning of CDI-specific therapy; T1, at the end of CDI-specific therapy.