Fig. 5.

Effect size by eosinophil cut-off in pooled analysis of SUN, SHINE and US3. Effect size by eosinophil cut-off in pooled analysis of SUN, SHINE and US3 for A) time to first CID event (hazard ratio [HR]) and B) number of events (risk ratio [RR]). Note: The solid line represents HR or RR of 1.0, while the dotted line represents treatment effect for the whole population. At each individual eosinophil count plotted, HR is calculated for the lower stratum in yellow (indicating the mean HR for all patients with an eosinophil count at or below cut-off) and the upper stratum in purple (indicating the mean HR for all patients above the cut-off). Example HR presented for cut-off at 0.15 x10⁹/L (vertical dotted line). The eosinophil range used here is narrower than the actual eosinophil range. There were a relatively small number of patients with higher values at a cut-off of 0.36 x10⁹/L, thus relevant analyses cannot be obtained in the upper strata if it were extended beyond this cut off