Table 1.

List of differentially expressed miRNAs detected by miRNA microArray

miRBase accession	miRNA name	NMDA		Bicuculline
		fold change	p adj.	fold change	p adj.
MI0004654	mmu-miR-689	5.24	0.07	0.91	1.00
MIMAT0004893	mmu-miR-574-5p	2.38	0.10	1.02	1.00
MIMAT0005837	mmu-miR-1187	2.21	0.09	1.03	1.00
MIMAT0003469	mmu-miR-690	2.12	0.10	1.00	1.00
MIMAT0003499	mmu-miR-709	1.99	0.23	0.90	1.00
MIMAT0007867	mmu-miR-1895	1.87	0.15	0.99	1.00
MIMAT0005846	mmu-miR-467f	1.79	0.14	0.98	1.00
MIMAT0003731	mmu-miR-671-5p	1.73	0.10	0.97	1.00
MIMAT0005834	mmu-miR-466i-3p	1.50	0.10	0.99	1.00
MIMAT0003182	mmu-miR-494-3p	1.35	0.15	1.00	1.00
MIMAT0003505	mmu-miR-714	1.34	0.22	1.01	1.00
MIMAT0007864	mmu-miR-1897-5p	1.30	0.36	1.01	1.00
MIMAT0007874	mmu-miR-1904	1.30	0.21	1.02	1.00
MIMAT0004882	mmu-miR-466f-3p	1.28	0.18	0.97	1.00
MIMAT0007878	mmu-miR-1894-3p	1.28	0.22	1.00	1.00
MIMAT0003495	mmu-miR-705	1.28	0.15	1.02	1.00
MIMAT0005839	mmu-miR-669f-3p	1.22	0.15	0.99	1.00
MIMAT0003502	mmu-miR-712-5p	1.22	0.15	1.02	1.00
MIMAT0004883	mmu-miR-466 g	1.21	0.23	0.99	1.00
MIMAT0017053	mmu-miR-212	1.02	0.95	1.86	0.72
MIMAT0016984	mmu-miR-132	1.06	0.85	1.38	1.00

Differential expression of miRNAs after activation of extrasynaptic vs. synaptic signaling. miRNA microarray data for the most strongly regulated miRNAs are shown. Extrasynaptic signaling was induced by bath application of NMDA (20 μM). Synaptic signaling was induced by application of the GABA-A receptor antagonist, bicuculline (50 μM) to reduce tonic network inhibition and thereby increase global synaptic activity. Fold-changes compared to untreated cells were calculated from three independent experiments. P-values were determined by two-tailed t test and adjusted with Benjamini-Hochberg correction for multiple testing