Table 2.
Allele and genotype frequency (%) in patients with IS and healthy controls
| Allele/genotype | Patients N = 211 | Controls N = 83 | Independent model P-value | P-value | OR (95% CI) |
|---|---|---|---|---|---|
| rs1017861 | |||||
| G | 87.7 | 74.6 | 0.0001a | 2.4 (1.5–3.8) | |
| A | 12.3 | 25.4 | |||
| GG | 77.2 | 55.4 | 0.0006 | 0.06b | 3.3 (0.9–12.7) |
| GA | 28 | 38.6 | |||
| AA | 1.9 | 6.0 | 0.002c | 0.4 (0.2–0.6) | |
| rs4738824 | |||||
| G | 81.8 | 79.5 | 0.53a | 0.84 (0.6–1.2) | |
| A | 18.3 | 20.5 | |||
| GG | 65.9 | 63.9 | 0.54 | 0.47b | 2.1 (0.6–7.9) |
| GA | 31.7 | 32.1 | |||
| AA | 2.4 | 4.8 | 0.84 c | 0.9 (0.5–1.6) | |
| rs4738813 | |||||
| T | 68.7 | 69.3 | 0.97a | 0.97 (0.66–1.44) | |
| C | 31.2 | 30.7 | |||
| TT | 48.2 | 49.4 | 0.98 | 0.99b | 0.99 (0.44–2.25) |
| CT | 41 | 39.8 | |||
| CC | 10.8 | 10.8 | 0.97c | 0.96 (0.58–1.59) | |
Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: a – alleles, b – dominant model, c – recessive model
significant P-values (<0.05) are in bold