Table 4.
Allele and genotype distribution between patients with different severity of IS
| Allele/genotype | Cobb angle ≤ 30° N = 87 | Cobb angle ≥ 35° N = 118 | Independent model P-value | P-value | OR (CI 0.95) |
|---|---|---|---|---|---|
| rs1017861 | |||||
| G | 93.7 | 83.5 | 0.0030a | 2.93 (1.46–5.91) | |
| A | 6.3 | 16.5 | |||
| GG | 88.5 | 69.5 | 0.0055 | 0.64b | 2.24 (0.23–21.95) |
| GA | 10.3 | 28.0 | |||
| AA | 1.2 | 2.5 | 0.0022c | 3.38 (1.6–7.27) | |
| rs4738824 | |||||
| G | 83.3 | 80.5 | 0.55a | 1.21 (0.72–2.02) | |
| A | 16.7 | 19.5 | |||
| GG | 68.9 | 63.6 | 0.65 | 0.91b | 1.1 (0.18–6.78) |
| GA | 28.7 | 33.9 | |||
| AA | 2.3 | 2.5 | 0.51c | 1.27 (0.71–2.29) | |
| rs4738813 | |||||
| T | 63.2 | 75.4 | 0.0104a | 0.56 (0.36–0.86) | |
| C | 36.8 | 24.6 | |||
| TT | 40.2 | 56.8 | 0.0221 | 0.0506b | 0.36 (0.14–0.94) |
| CT | 44.8 | 37.3 | |||
| CC | 14.9 | 5.9 | 0.0277c | 0.51 (0.29–0.89) | |
Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: a – alleles, b – dominant model, c – recessive model
significant P-values (<0.05) are in bold