Table 6.
Alleles and genotypes distribution between patients with different rate of progression of IS
| Independent model | Dominant model | Recessive model | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Allele/genotype | NP-IS N = 80 | SP-IS N = 78 | RP-IS N = 53 | P-valuea | P-value NP-IS vs. RP-ISa | P-valuea | P-value NP-IS vs. RP-ISb | P-valuea | P-value NP-IS vs. RP-ISa |
| rs1017861 | |||||||||
| G | 93.1 | 86.5 | 81.1 | 0.0124 | 0.0053 | ||||
| A | 6.9 | 13.5 | 18.9 | ||||||
| GG | 87.5 | 75.6 | 64.2 | 0.0316 | 0.005 | 0.83 | 1 | 0.0065 | 0.0029 |
| GA | 11.3 | 21.8 | 33.9 | ||||||
| AA | 1.3 | 2.5 | 1.9 | ||||||
| rs4738824 | |||||||||
| G | 83.1 | 80.8 | 81.1 | 0.85 | 0.80 | ||||
| AA | 16.9 | 19.2 | 18.9 | ||||||
| GG | 68.8 | 64.1 | 64.2 | 0.96 | 0.80 | 0.97 | 1 | 0.47 | 0.72 |
| GA | 28.8 | 33.3 | 33.9 | ||||||
| AA | 2.5 | 2.6 | 1.9 | ||||||
| rs4738813 | |||||||||
| T | 62.5 | 75. | 73.6 | 0.0338 | 0.08 | ||||
| C | 37.5 | 25. | 26.4 | ||||||
| TT | 38.8 | 62.8 | 50.9 | 0.0028 | 0.0483 | 0.06 | 0.0273 | 0.0103 | 0.23 |
| CT | 47.5 | 24.4 | 47.2 | ||||||
| CC | 13.8 | 12.8 | 1.9 | ||||||
Abbreviations: IS idiopathic scoliosis, NP-IS nonprogressive idiopathic scoliosis, SP-IS slowly progressive idiopathic scoliosis and RP-IS rapidly progressive idiopathic scoliosis, a- Chi-square test
significant P-values (<0.05) are in bold