Fig. 4.

Incidence rate ratio (IRR) for PPC by DLco status and surgical extent. (a) All patients. (b) All patients with lobectomy. (c) All patients with bilobectomy/pneumonectomy. (d) Patients with baseline normal DLco. (e) Patients with baseline normal DLco with lobectomy. (f) Patients with baseline normal DLco with bilobectomy/pneumonectomy. (g) Patients with baseline low DLco. (h) Patients with baseline low DLco with lobectomy. i) Patients with baseline low DLco with bilobectomy/pneumonectomy. There was a tendency to increase IRR for any postoperative pulmonary complication (PPC) when there was an approximately 20% decrement of DLco after neoadjuvant CCRT. In particular, the risk of PPC after bilobectomy or pneumonectomy sharply increased with greater than 20% of decrement of DLco after neoadjuvant CCRT in patients with low baseline DLco. DLco, diffusing capacity of the lung for carbon monoxide; CCRT, concurrent chemoradiotherapy