Table 1.
Characteristics of Study Populations by PPC Development (N = 321)
| Overall (N = 321) | Development of PPC | |||
|---|---|---|---|---|
| No (N = 242) | Yes (N = 79) | P Value | ||
| Age (years) | 61.1 (8.0) | 60.4 (8.0) | 63.3 (8.0) | .006 |
| Sex | .017 | |||
| Male | 289 (80.7) | 188 (77.7) | 71 (89.9) | |
| Female | 62 (19.3) | 54 (22.3) | 8 (10.1) | |
| BMI (kg/m2) | 23.7 (3.1) | 23.8 (3.1) | 23.6 (3.1) | .670 |
| Smoking status | .014 | |||
| Never | 63 (19.6) | 55 (22.7) | 8 (10.1) | |
| Past or current | 259 (80.4) | 187 (77.3) | 71 (89.9) | |
| Histology | .120 | |||
| Adenocarcinoma | 168 (52.3) | 134 (55.4) | 34 (43.0) | |
| Squamous cell | 128 (39.8) | 90 (37.2) | 38 (48.1) | |
| Large cell | 9 (2.8) | 8 (3.3) | 1 (1.3) | |
| Others | 16 (5.0) | 10 (4.1) | 6 (7.6) | |
| Type of surgery | .010 | |||
| Lobectomy | 256 (79.8) | 201 (83.1) | 55 (69.6) | |
| Bilobectomy/Pneumonectomy | 65 (20.2) | 41 (16.9) | 24 (30.4) | |
| PFT before CCRT | ||||
| FVC, % of the predicted value | 91.7 (15.1) | 92.7 (14.8) | 88.6 (15.8) | .036 |
| FEV1, % of the predicted value | 82.8 (16.6) | 84.4 (16.5) | 77.8 (15.9) | .002 |
| FEV1/FVC, % | 70.2 (9.6) | 70.9 (9.4) | 68.1 (10.1) | .003 |
| DLco, % of the predicted value | 82.0 (17.5) | 84.7 (17.7) | 73.7 (14.1) | <.001 |
| PFT after CCRT | ||||
| FVC, % of the predicted value | 90.3 (13.7) | 91.8 (13) | 85.6 (14.8) | <.001 |
| FEV1, % of the predicted value | 84.4 (14.6) | 85.9 (14.1) | 79.8 (15.2) | .001 |
| FEV1/FVC, % | 70.8 (9.0) | 71.2 (8.7) | 69.5 (9.8) | .143 |
| DLco, % of the predicted value | 69.7 (15.1) | 72 (14.9) | 62.8 (13.6) | <.001 |
| Hemoglobin | ||||
| Before CCRT | 13.6 (1.4) | 13.6 (1.4) | 13.5 (1.6) | 0.793 |
| After CCRT | 11.9 (1.5) | 11.9 (1.5) | 11.9 (1.6) | 0.725 |
Values in table are mean (SD), number (%), or median (interquartile range)
BMI body mass index; CCRT concurrent chemoradiotherapy; DLco diffusing capacity of the lung for carbon monoxide; FEV1 forced expiratory volume in one second; FVC forced vital capacity; PFT pulmonary function test; PPC postoperative pulmonary complications