Table 3.
Incidence Rate Ratio (95% Confidence Intervals) for PPCs by DLco Status
| Crude IRR (95% CI) | Model 1 IRR (95% CI) | Model 2 IRR (95% CI) | |
|---|---|---|---|
| DLco at diagnosis | |||
| Normal (N = 165) | Reference | Reference | Reference |
| Low (N = 156) | 2.42 (1.58, 3.72) | 2.14 (1.38, 3.30) | 2.14 (1.36, 3.36) |
| P value | < .001 | .001 | .001 |
| Dlco Before And After CCRT | |||
| NN: Normal → Normal (N = 76) | Reference | Reference | Reference |
| NL: Normal → Low (N = 89) | 2.07 (0.91, 4.74) | 2.01 (0.88, 4.60) | 2.05 (0.89, 4.73) |
| LL: Low → Low (N = 75) | 3.33 (1.52, 7.30) | 3.00 (1.34, 6.73) | 3.03 (1.34, 6.89) |
| LVL: Low → Very Low (N=81) | 4.29 (2.01, 9.14) | 3.63 (1.67, 7.88) | 3.78 (1.68, 8.49) |
| P for trends | < .001 | .004 | .005 |
CCRT concurrent chemoradiotherapy; CI confidence intervals; DLco diffusing capacity of the lung for carbon monoxide; FEV1 forced expiratory volume in one second; FVC forced vital capacity; IRR incidence rate ratio; PPC postoperative pulmonary complication
Model 1: Adjusted for age, sex and type of surgery (lobectomy vs others)
Model 2: Further adjusted for post CCRT airflow limitation (FEV1 / FVC < 70%), and post CCRT hemoglobin