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. 2020 Jan 10;12:10. doi: 10.1186/s13148-019-0802-2

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© The Author(s). 2020

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Epigenetic craniofacial enhancer analysis. Epigenetic analysis of conserved craniofacial enhancer element hs1431 shown as Genome Browser tracks of aligned indicated ChIP Seq signal peaks. Y-axis indicates coverage by estimated fragments normalized to millions of reads mapped generated from next generation sequencing. Experiments are from mouse 4 days old embryoid bodies (MLL3^−/−;MLL4^flox/flox) [48] and e11.5 embryonic mouse facial tissu e[128]. Data analyzed are publically available from Gene Expression Omnibus database (accession numbers GSE50534 and GSE49413). Data analysis, peak calling, and visualization were performed in BioWardrobe [130] with GRCm38/mm10 genome build