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Comparison of apoptosis, necroptosis and pyroptosis
| Apoptosis | Necroptosis | Pyroptosis | ||
|---|---|---|---|---|
| Initiating | Program | Random | Program | |
| Signaling pathway | Caspase-3/7/8 | TNF-α | Caspase-1/11 | |
| Terminal event | Membrane pore formation | No | MLKL | GSDMD |
| Cell swelling | No | Yes | Yes | |
| PI staining | No | Yes | Yes | |
| LDH release | No | Yes | Yes | |
| TUNEL | Yes | Yes | Yes | |
| Tissue effect | Inflammatory | No | Yes | Yes |
| IL-1β release | No | No | Yes | |
