Table 1.

Classification categories and definitions in Pharao® and Renbase® [8–10]

Classification	Definition
	Pharao	Renbase
A	No known pharmacological or clinical basis for an increased risk.	No need for dosage modification.
B	There is a somewhat increased risk.	The information is not available or the recommendation is estimated based on the pharmacokinetic characteristics of the substance.
C	There is a moderately increased risk.	Modification of the dose or dosage interval is needed.
D	There is a high risk.	The use should be avoided.
0	No pharmacological effect.	–
1	A mild pharmacological effect.	–
2	A moderate pharmacological effect.	–
3	A strong pharmacological effect.	–