Skip to main content
. 2020 Jan 10;18:2. doi: 10.1186/s12969-020-0399-1

Table 1.

Demographic and clinical features of patients with macrophage activation syndrome

Tocilizumab Historic cohort
Full-blown Possible All Full-blown Possible All
Number 2 10 12 10 8 18
Sex, no.
 Female 1 7 8 3 5 8
 Male 1 3 4 7 3 10
 Age, median (IQR) 6 (3–9) 8.5 (7–14.75) 8.5 (7–12.75) 5 (1.75–6.75) 8 (3.5–9.5) 5.5 (2–8.25)
 Fever (%, n) 50 (1/2) 50 (5/10)* 50 (6/12)** 90 (9/10) 100 (8/8)* 94.4 (17/18)**
 Hepatosplenomegaly (%, n) 0 (0/2) 30 (3/10) 25 (3/12) 40 (4/10) 37.5 (3/8) 38.9 (7/18)
 Lymphadenopathy (%, n) 0 (0/2) 20 (2/10) 16.7 (2/12) 30 (3/10) 37.5 (3/8) 33.3 (6/18)
 CNS (%, n) 0 (0/2) 0 (0/10) 0 (0/12) 0 (0/10) 0 (0/8) 0 (0/18)

CNS Central nervous system, * = p < 0.05; ** = p < 0.01;