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Target residues for library LibM2. Residues mutated in library M2 (magenta) surround the substrate binding site. Residue Thr142 and xylose (yellow) may interact (dashed lines) via a water molecule (red sphere). Magnesium ions and the coordinating residues are depicted as green spheres and gray. The metal binding residues and conserved active site hydrophobic residues Phe146 and Trp189 are shown as gray sticks. PDB 5NH7
