Table 1.

Relative expression of selected DEGs in ToF vs ASD specimens

Function	Gene symbol	Gene description	Fold changea
ToF
Matrix organization and cell adhesion	ELN	Elastin	3.9
	POSTN	Periostin, osteoblast specific factor	3.6
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	3.6
	COL1A1	Collagen, type I, alpha 1	3.5
	COL1A2	Collagen, type I, alpha 2	2.8
	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	2.8
	COL5A1	Collagen, type V, alpha 1	2.7
	VCAN	Versican	2.7
	COL5A2	Collagen, type V, alpha 2	2.6
	MMP16	Matrix metallopeptidase 16 (membrane-inserted)	2.5
	NID1	Nidogen 1	2.3
	COL4A4	Collagen, type IV, alpha 4	2.3
	COL4A1	Collagen, type IV, alpha 1	2.1
	THBS1	Thrombospondin 1	2.1
	LAMA2	Laminin, alpha 2	2.1
Trascription factors	EGR1	Early growth response 1	4.5
	FOS	FBJ murine osteosarcoma viral oncogene homolog	4.0
	HIF3A	Hypoxia inducible factor 3, alpha subunit	2.2
	IER2	Immediate early response 2	2.1
	NFIL3	Nuclear factor, interleukin 3 regulated	2.0
ASD
Muscle development and contraction	ACTA1	Actin, alpha 1, skeletal muscle	9.6
	NEB	Nebulin	7.9
	MYOT	Myotilin	6.4
	MYL3	Myosin, light chain 3, alkali; ventricular, skeletal, slow	5.3
	KLHL41	Kelch-like family member 41	4.8
	MUSTN1	Musculoskeletal, embryonic nuclear protein 1	4.1
	PPP1R3A	Protein phosphatase 1, regulatory subunit 3A	3.9
	ENO3	Enolase 3 (beta, muscle)	3.6
	SYNPO2	Synaptopodin 2	3.4
	MYH11	Myosin, heavy chain 11, smooth muscle	2.0
	MURC	Muscle-related coiled-coil protein	2.0

Comparative analysis of gene expression in ToF and ASD samples was conducted as described in “Methods” section. A function, a gene symbol, a brief gene description, and the fold change values are specified for each gene

Genes for each functional category are ordered according to decreasing fold changes

^aFold change ≥ 2 are considered significant