Table 4.
Relative expression of genes selectively modulated in Post- vs Pre-CPB ToF samples
| Function | Gene symbol | Gene description | Fold changea |
|---|---|---|---|
| Transcription regulation | IRF1 | Interferon regulatory factor 1 | 10.3 |
| BHLHE40 | Basic helix-loop-helix family, member e40 | 4.4 | |
| MIR612/NEAT1 | MicroRNA 612/ nuclear paraspeckle assembly transcript 1 | 3.7 | |
| KLF10 | Kruppel-like factor 10 | 3.1 | |
| BCL3/MIR8085 | B-cell CLL/lymphoma 3/microRNA 8085 | 3.1 | |
| IFRD1 | Interferon-related developmental regulator 1 | 2.9 | |
| DDIT3 | DNA-damage-inducible transcript 3 | 2.7 | |
| SOX9 | SRY (sex determining region Y)-box 9 | 2.5 | |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 2.4 | |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 2.1 | |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.0 | |
| AFF4 | AF4/FMR2 family, member 4 | 2.0 | |
| Inflammatory responses | CXCL8 | Chemokine (C-X-C motif) ligand 8 | 19.6 |
| IL6 | Interleukin 6 | 18.7 | |
| AREG | Amphiregulin | 10.1 | |
| TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 | 3.0 | |
| IL1RL1 | Interleukin 1 receptor-like 1 | 2.8 | |
| SQSTM1 | Sequestosome 1 | 2.7 | |
| HSPA1A,1B | Heat shock 70kDa protein 1A,1B | 2.2 | |
| KDM6B | Lysine (K)-specific demethylase 6B | 2.0 | |
| C1QC | Complement component 1, q subcomponent, C chain | 0.5 | |
| C1QB | Complement component 1, q subcomponent, B chain | 0.4 | |
| Cell adhesion, cytoskeleton and matrix organization | ABRA | Actin-binding Rho activating protein | 8.5 |
| THBS1 | Thrombospondin 1 | 7.9 | |
| PDLIM3 | PDZ and LIM domain 3 | 5.3 | |
| MMP19 | Matrix metallopeptidase 19 | 4.6 | |
| FBN2 | Fibrillin 2 | 2 4 | |
| XIRP1 (CMYA1) | Xin actin-binding repeat containing 1 | 3.6 | |
| HBEGF | Heparin-binding EGF-like growth factor | 2.6 | |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88 kDa | 2 | |
| Antioxidant activity | MT1X | Metallothionein 1X | 3.9 |
| MT1F | Metallothionein 1F | 3.1 | |
| MT1HL1 | Metallothionein 1H-like 1 | 3.1 | |
| MT1H | Metallothionein 1H | 2.9 | |
| MT1E | Metallothionein 1E | 2.9 | |
| MT1G | Metallothionein 1G | 2.5 | |
| DNA repair | SPIDR | Scaffolding protein involved in DNA repair | 5.5 |
| PPP1R10 | Protein phosphatase 1, regulatory subunit 10 | 2.1 |
Comparative analysis of gene expression in Pre-CPB and Post-CPB ToF samples was conducted as described in “Methods” section. A main function, a gene symbol, a brief gene description, and the fold change values are specified for each gene
Genes for each functional category are ordered according to decreasing fold changes
aFold change was calculated as the ratio between the mean expression value of Post-ToF and Pre-ToF samples for each gene. Fold changes ≥ 2 or ≤ 0.5 are considered significant