Table 5.

Relative expression of genes selectively modulated in Post- vs Pre-CPB ASD samples

Function	Gene symbol	Gene description	Fold changea
Inflammatory response	KDR (FLK1, VEGFR)	Kinase insert domain receptor (type III receptor tyrosine kinase), VEGF receptor	0.5
	C4A/C4B	Complement component 4A (Rodgers blood group)/4B (Chido blood group)	0.4
	CFIv	Complement factor I	0.3
	CFB	Complement factor B	0.2
	SLPI	Secretory leukocyte peptidase inhibitor	0.2
Cell adhesion	PTPRF	Protein tyrosine phosphatase, receptor type, F	0.4
	FLRT3	Fibronectin leucine rich transmembrane protein 3	0.2
	MSLN	Mesothelin	0.16
	PRG4	Proteoglycan 4	0.13
Oxidative stress	PTGIS	Prostaglandin I2 (prostacyclin) synthase	0.5
	AOX1	Aldehyde oxidase 1	0.5

Comparative analysis of gene expression in Pre-CPB and Post-CPB ToF samples was conducted as described in “Methods” section. A main function, a gene symbol, a brief gene description, and the fold change values are specified for each gene

Genes for each functional category are ordered according to decreasing fold changes

^aFold change was calculated as the ratio between the mean expression value of Post-ToF and Pre-ToF samples for each gene. Fold changes ≥ 2 or ≤ 0.5 are considered significant