Table 6.
Hypoxia-related gene sets enriched in Post- vs Pre-CPB ASD samples
| GSEA terma | NOM p-valb | FDR q-valc |
|---|---|---|
| GROSS_ELK3_TARGETS_DN | 0.002 | 0.012 |
| CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP | 0.018 | 0.014 |
| BIOCARTA_CARDIACEGF_PATHWAY | 0.002 | 0.014 |
| LEONARD_HYPOXIA | 0.002 | 0.011 |
| GROSS_HYPOXIA_VIA_ELK3_DN | 0.026 | 0.030 |
| GROSS_HYPOXIA_VIA_ELK3_ONLY_UP | 0.016 | 0.043 |
| MENSE_HYPOXIA_UP | 0.012 | 0.042 |
| KRIEG_HYPOXIA_VIA_KDM3A | 0.042 | 0.095 |
| HARRIS_HYPOXIA | 0.053 | 0.096 |
| HU_ANGIOGENESIS_UP | 0.048 | 0.101 |
| KIM_HYPOXIA | 0.050 | 0.142 |
Gene sets are ordered according to increasing FDR q-val
aGene sets enriched in the GSEA analysis. Gene sets belonging to all curated collections o f the MSigDB were selected using the keywords “hypoxia” and “heart” and filtering out those having less than 15 probe sets and more than 500 probe sets
bNOM p-val measures the statistical significance of the normalized enriched score by an empirical permutation test using 1.000 gene permutations. NOM p-val ≤ 0.05 are considered significant
cFDR q-value is the estimated probability that the normalized enrichment s core represents a false positive finding. Values ≤ 0.2 are considered significant