Figure 1.

Primary sequence of the human FAM181A and FAM181B proteins. (a). Primary sequence of FAM181A and FAM181B from UniProt. The amino acids in bold correspond to FAM181A^127–205 and FAM181B^157–237. The residues belonging to the Ω‐loop are in blue. Val190^FAM181A and Val220^FAM181B are in orange. The LxxLF motif present in FAM181B is colored green. (b). The primary sequences of YAP57‐99, FAM181A^127–205 and FAM181B^157–235 were manually aligned. The secondary structure adopted by YAP upon binding to TEAD is indicated.16 α: α‐helix; Ω: Ω‐loop. Dashes (−) indicate gaps. The colors are the same as in (a)