Figure 1.

Study design. For the rat model of wound repair under physiological conditions, full‐thickness wounds were created bilaterally on the dorsal aspect of the hind paws. One day after wounding, animals were treated either with a single injection of 2 × 10⁶ ASCs systemically into the tail vein or locally with 2 × 10⁵ ASCs in total, split into two sides of each wound. Control animals received a single injection of NaCl systemically into the tail vein. Animals were followed by digital photography and bioluminescence imaging and sacrificed for the collection of tissues for histology at 3 hours, 24 hours, 48 hours, 72 hours, 7 days, and 15 days post‐treatment and at wound closure. Abbreviations: ASCs, adipose‐derived mesenchymal stromal cells; Fluc, firefly luciferase; GFP, green fluorescent protein