Table 4.
Safety and Comparison of Adverse Events
| Adverse Event | All Patients* (n=254) | First-Treated Patients (n=108) | Re-Treatment Patients (n=146) | P value |
|---|---|---|---|---|
| Diarrhea, no. (%) | 11 (4.3) | 6 (5.6) | 5 (3.4) | 0.608 |
| Black stool, no. (%) | 246 (96.9) | 105 (97.2) | 141 (96.6) | 1.000 |
| Nausea/Vomiting, no. (%) | 8 (3.1) | 5 (4.6) | 3 (2.1) | 0.425 |
| Abdominal pain, no. (%) | 9 (3.5) | 4 (3.7) | 5 (3.4) | 1.000 |
| Flatulence, no. (%) | 4 (1.6) | 2 (1.9) | 2 (1.4) | 1.000 |
| Belching, no. (%) | 5 (2.0) | 2 (1.9) | 3 (2.1) | 1.000 |
| Heart burn, no. (%) | 7 (2.8) | 3 (2.8) | 4 (2.7) | 1.000 |
| Skin rash, no. (%) | 3 (1.2) | 1 (0.9) | 2 (1.4) | 1.000 |
| Headache, no. (%) | 7 (2.8) | 4 (3.7) | 3 (2.1) | 0.685 |
| Dysgeusia, no. (%) | 68 (26.8) | 43 (39.8) | 25 (17.1) | <0.001 |
| Fever, no. (%) | 4 (1.6) | 2 (1.9) | 2 (1.4) | 1.000 |
| Constipation, no. (%) | 4 (1.6) | 1 (0.9) | 3 (2.1) | 0.838 |
| Anorexia, no. (%) | 5 (2.0) | 3 (2.8) | 2 (1.4) | 0.733 |
| Fatigue, no. (%) | 6 (2.4) | 2 (1.9) | 4 (2.7) | 0.966 |
| Dizziness, no. (%) | 6 (2.4) | 3 (2.8) | 3 (2.1) | 1.000 |
Notes: *Two hundred and sixty-one patients were retrospectively analyzed and 7 patients had not been treated by any regimen because 6 patients were resistant to all available antibiotics and one patient was intractable.