Table 3. Dose adjustment of direct oral anticoagulants in non-valvular atrial fibrillation.

Direct oral anticoagulant	Clinical factors	Dose adjustment
Apixaban	At least two of: • serum creatinine ≥133 micromol/L • age ≥80 years • weight ≤60 kg	5 mg twice a day to 2.5 mg twice a day
Rivaroxaban	At least one of: • CrCl 30–49 mL/min • combination with dual antiplatelet therapy	20 mg daily to 15 mg daily
Dabigatran	At least one of: • CrCl 30–50 mL/min • age ≥75 years • combination with dual antiplatelet therapy	150 mg twice a day to 110 mg twice a day

CrCl creatinine clearance

Source: reference 3