Table 1.
Characteristics of tissue-resident memory ILCs and conventional memory NK cells
| Conventional memory NK | Tissue-resident memory ILCs | ||||
|---|---|---|---|---|---|
| Ly49H+cNK | cNK | trNK | ILC1 | ILC2 | |
| Tissue-residency | - | - | liver | LNs, liver | LNs, Lung |
| Antigen specify | MCMV-m157 | IL-12/15/18 (non-specific) | Haptens, Influenza, VSV, HIV | Haptens | IL-33 (non-specific) |
| Recall responses |
IFN-γ ↑ Cytotoxicity ↑ Expansion ↑ |
IFN-γ ↑ |
IFN-γ ↑ Cytotoxicity ↑ |
Inflammation ↑ |
IL-5 ↑ IL-13 ↑ |
| Longevity | + | + | + | + | + |
MCMV, mouse cytomegalovirus; cNK, conventional NK cells; trNK, tissue-resident NK cells; LNs, lymph nodes; VSV, vesicular stomatitis virus; HIV, human immunodeficiency virus