Table 2.

Neurophysiological differences between MND patients and controls, by muscle, at baseline, listed in order of maximal MUNIX differences

Muscle	Percentage differences between patients and controls (95% CI)
	MUNIX	p value	MUSIX	p value	CMAP	p value
Abductor pollicis brevis	− 50 (− 67, − 34)	< 0.001*	17 (− 4, 39)	0.115	− 37.7 (− 55.3, − 20.1)	< 0.001*
Abductor hallucis	− 50 (− 71, − 29)	< 0.001*	− 7 (− 33, 20)	0.611	− 41.5 (− 61.1, − 21.8)	< 0.001*
Extensor digitorum brevis	− 44 (− 69, − 19)	0.001*	− 21 (− 51, 10)	0.180	− 41.8 (− 64.0, − 19.6)	< 0.001*
Tibialis anterior	− 39 (− 56, − 22)	< 0.001*	43 (11, 76)	0.011*	− 22.2 (− 40.2, − 4.3)	0.016*
Biceps brachii	− 36 (− 52, − 20)	< 0.001*	4 (− 8, 16)	0.522	− 30.2 (− 46.6, − 13.9)	0.001*
Abductor digiti minimi	− 34 (− 51, − 16)	< 0.001*	20 (− 1, 41)	0.057	− 29.4 (− 45.5, − 15.3)	< 0.001*

Significant differences between MND patients and controls are highlighted in bold. Results surviving multiple comparisons correction are asterisked. The least affected muscle in each patient and the right side in controls were tested

CI confidence interval, CMAP compound muscle action potential, MUNIX motor unit number index, MUSIX motor unit number size