Table 3.
Clinico-electrophysiological-radiological associations in MND patients
| Muscle | Mean (SD) dynamometry (lb) |
Mean (SD) MUNIX | Clinico-radiological association coefficient (95% CI) | p value | Electro-physiological-radiological association coefficient (95% CI) | p value |
|---|---|---|---|---|---|---|
| Right biceps | Not tested | 129.3 (53.9) | Not tested | Not tested | 9.7 (− 128.9, 148.4) | 0.885 |
| Left biceps | ||||||
| Right first dorsal interosseous | 4.8 (3.5) | Not tested | − 10.9 (− 17.0, − 4.8) | 0.001* | Not tested | Not tested |
| Left first dorsal interosseous | 4.7 (3.4) | − 6.6 (− 11.8, − 1.5) | 0.014* | |||
| Right abductor pollicis brevis | 6.4 (4.6) | 82.8 (52.2) | − 13.7 (− 24.5, − 2.9) | 0.015* | − 74.2 (− 207.1, 58.7) | 0.258 |
| Left abductor pollicis brevis | 7.0 (5.1) | 6.0 (− 3.4, 15.4) | 0.199 | |||
| Right abductor digiti minimi | 3.4 (2.1) | 123.2 (68.0) | − 8.0 (− 16.4, 0.4) | 0.061 | − 86.9 (− 380.9, 207.1) | 0.543 |
| Left abductor digiti minimi | 2.9 (1.9) | − 6.4 (− 12.2, − 0.6) | 0.034 | |||
| Right quadriceps | 42.8 (11.5) | Not tested | − 56.6 (− 84.8, − 28.4) | < 0.001* | Not tested | Not tested |
| Left quadriceps | 43.6 (12.6) | − 51.2 (− 82.0, − 20.4) | 0.002* | |||
| Right tibialis anterior | 34.0 (19.8) | 83.5 (48.6) | − 93.0 (− 122.2, − 63.8) | < 0.001* | − 232.0 (− 343.1, − 120.9) | < 0.001* |
| Left tibialis anterior | 36.5 (21.8) | − 108.1 (− 133.6, − 82.6) | < 0.001* |
Significant associations between dynamometry scores, motor unit number index and relative T2-signal in corresponding muscles are reported in bold. Results surviving multiple comparisons correction are asterisked. Electrophysiological measures were derived from the least affected side in patients and regressed against clinical measures of corresponding laterality
CI confidence interval, lb, pounds force, MUNIX motor unit number index, SD standard deviation