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. 2019 Sep 26;267(1):76–86. doi: 10.1007/s00415-019-09552-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — a Concentrations of MCP-1, IL-8 and IL-10 in serum of FTLD patients carrying or not the C9orf72 HRE measured using single molecule array (Simoa). The data for IL-1β is not shown due to extremely low concentrations observed in most cases. b Plasma MCP-1 and RANTES, measured using cytometric bead array (CBA). a, b Symbols represent separate cases, and horizontal lines represent median with interquartile range. Mann–Whitney U test was used to compare groups separately. For IL-8 and RANTES, the significant p value is calculated for all males compared to all females, regardless of the C9orf72 HRE status (comparison between genders). For IL-10, the difference between male C9orf72 HRE carriers and non-carriers was significant when outliers were excluded (p = 0.049)