Table 2.
Inflammatory molecule concentrations and peripheral blood cell counts in FTLD patients with and without the C9orf72 HRE
| Molecules | FTLD with C9orf72 HRE | FTLD without C9orf72 HRE | p value | ||||
|---|---|---|---|---|---|---|---|
| Males | Females | Males and females | Males | Females | Males and females | ||
| Plasma MCP-1 (pg/ml) | 52.51 (56.58) | 46.12 (38.68) | 47.98 (46.09) | 25.26 (38.71) | 36.74 (62.38) | 34.05 (50.96) | NS |
| Plasma RANTES (pg/ml) | 5758.24 (6141.67) | 8508.65 (7768.83) | 6878.30 (4453.53) | 7400.79 (6469.65) | 9343.94 (4195.54) | 8349.42 (4433.47) | NS |
| Serum MCP-1 (pg/ml) | 364.57 (92.42) | 481.91 (233.92) | 390.43 (190.43) | 359.51 (183.52) | 378.80 (186.89) | 377.60 (169.89) | NS |
| Serum IL-10 (pg/ml) | 1.31 (1.00) | 0.85 (0.99) | 1.21 (0.84) | 0.86 (0.80) | 0.97 (1.22) | 0.90 (0.83) | NS* |
| Serum IL-8 (pg/ml) | 32.89 (31.84) | 51.28 (30.52) | 44.69 (39.76) | 34.76 (22.35) | 47.23 (36.90) | 39.28 (28.24) | NS |
| Serum IL-1β (pg/ml) | 1.52 (2.93) | 0.30 (NA) | 0.37 (1.38) | 0.71 (3.25) | 0.50 (6.35) | 0.51 (4.23) | NS |
| hs-CRP (mg/l) | 0.60 (0.43) | 2.10 (3.10) | 1.00 (1.90) | 0.80 (1.55) | 1.40 (4.38) | 1.20 (2.70) | NS |
| Leukocytes (×109/l) | 5.60 (1.80) | 5.95 (3.58) | 5.60 (2.80) | 6.50 (2.70) | 6.00 (1.95) | 6.40 (2.10) | NS |
| Thrombocytes (×109/l) | 198 (34.00) | 258 (85.50) | 2141 (88.50) | 228 (115.00) | 279 (66.25) | 2721 (101.25) | 0.0391 |
| Hemoglobin (g/l) | 1531 (13.0) | 139 (9.5) | 1442 (16.0) | 1391 (18.5) | 136 (16.3) | 1372 (16.0) |
0.0011 0.0042 |
Concentrations are presented as median (interquartile range, IQR). Plasma MCP-1 and RANTES were analyzed with cytometric bead array, and serum MCP-1, IL-10, IL-8 and IL-1β with single molecule array. Mann–Whitney U test was used to compare groups separately (three comparisons per row: between all C9orf72 HRE carriers and non-carriers, between male carriers and male non-carriers, and between female carriers and female non-carriers). Comparisons between genders are presented in Figs. 1 and 2
p value column presents statistically significant differences in each row, and the superscript numbers indicate which two groups were compared
NS indicates no significant differences in any of the three separate pairwise comparisons per row
*In IL-10 levels, C9orf72 HRE carrier males showed a trend for higher IL-10 concentration compared to non-carrier males (p = 0.093), being significant when outliers were excluded (p = 0.049)