Figure 3; Loss of NRK2 promotes cardiac hypertrophy, scar expansion and heart failure post-MI.
(A) Morphometric parameters including heart weight and lung weight to tibia length ratios show an increased cardiac hypertrophy and heart failure in the KO vs control mice post-MI, n=5–6. (B) Representative images of Masson’s trichrome- stained control and KO heart sections show a dilated LV chamber and extensive scar in the KO post-MI. Bar diagram shows (C) an increased scar circumference and (D) decreased thickness in the post-MI KO hearts, n=5–6. ns, non-significant; *p<0.05; **p<0.005.