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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2019 Nov 16;1866(3):165609. doi: 10.1016/j.bbadis.2019.165609

Figure 8; Loss of NRK-2 exaggerate P38 activation and cardiac remodeling in ischemic heart:

Figure 8;

Schematic diagram shows that β1-integrin binding protein NRK-2 inhibits P38α activation however, loss of NRK-2 leads to exaggerated P38α activation in turn promotes dilatative cardiac remodeling and fibrosis post-MI.