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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Neuropharmacology. 2019 Dec 2;164:107901. doi: 10.1016/j.neuropharm.2019.107901

Figure 2.

Figure 2.

Systemic administration of TAT-P4-(DATC5)2 dose-dependently attenuates cocaine priming-induced reinstatement of drug-seeking behavior. (A) Cocaine seeking was significantly decreased in rats pretreated with 3.0 nmol/g TAT-P4-(DATC5)2 (i.v.) compared to vehicle-treated controls (n=5/treatment). (B) Dose-dependent effects of TAT-P4-(DATC5)2 were tested in a separate cohort of rats (n=6/treatment). Cocaine seeking was significantly reduced in rats pretreated with 3.0 nmol/g TAT-P4-(DATC5)2 (i.v.) compared to vehicle-treated controls and rats pretreated with 0.3 nmol/g TAT-P4-(DATC5)2. No effects of TAT-P4-(DATC5)2 on inactive lever responding were found in either experiment. *p<0.05, Bonferroni