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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Neuropharmacology. 2019 Dec 2;164:107901. doi: 10.1016/j.neuropharm.2019.107901

Figure 5.

Figure 5.

TAMRA-conjugated TAT-P4-(DATC5)2 penetrates cultured striatal medium spiny neurons. Representative confocal images of live striatal neurons showing the penetration of 5 μM TAMRA-C5 (magenta, top) or TAMRA-conjugated TAT-P4-(DATC5)2 (magenta, bottom) after 1 hr incubation at 37°C in conditioned media. The cell membrane is stained with DiO (light blue). The comparison between the control peptide TAMRA-C5 and TAMRA-conjugated TAT-P4-(DATC5)2 demonstrates the penetration capacity of the second compound over the first one. Scale bar: 10 μm and 3 μm on the orthogonal views zoom.