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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Neuropharmacology. 2019 Dec 2;164:107901. doi: 10.1016/j.neuropharm.2019.107901

Figure 7.

Figure 7.

Administration of TAT-P4-(DATC5)2 directly into the nucleus accumbens shell dose-dependently attenuated cocaine priming-induced reinstatement of drug-seeking behavior. (A) Infusions of TAT-P4-(DATC5)2 (3.0 pmol/μl) directly into the shell prior to a cocaine priming injection reduced active lever responses during subsequent reinstatement test sessions compared to vehicle-treated controls and rats pretreated with 0.3 pmol/μl TAT-P4-(DATC5)2 (n=9/treatment). (B) Administration of TAT-P4-(DATC5)2 directly into the accumbens shell did not affect the reinstatement of sucrose seeking (n=7/treatment). Intra-shell microinjection sites for the cocaine and sucrose reinstatement studies are shown in C & D, respectively. *p<0.05, Bonferroni