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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Neuropharmacology. 2019 Dec 4;164:107906. doi: 10.1016/j.neuropharm.2019.107906

Figure 1.

Figure 1.

Experimental procedure. A. Group 1: Rats underwent 21 sessions of oxycodone self-administration (12 h/day, 5 days/week) in the presence of a discriminative stimulus (Sd), followed by 14 extinction sessions (2 h/day, 7 days/week). After extinction, the rats were tested repeatedly for the cue-induced reinstatement of oxycodone seeking (2 h/session). Sn, reinstatement test with neutral stimuli; Sd, reinstatement test with discriminative stimuli. B. Groups 2 and 3: Rats were tested for the ability of SB334867 and TCSOX229 to reduce oxycodone intake during 12-h self-administration sessions. The tests were performed every other day starting on day 14 of self-administration. C. Groups 4 and 5: Following self-administration and extinction training, the rats were tested for the ability of SB334867 and TCSOX229 to decrease oxycodone seeking during 2 h cue-induced reinstatement tests (Sd). Sn, reinstatement test with neutral stimuli; Sd, reinstatement test with discriminative stimuli.