Table 3a.
Comparison of sensitivity and specificity estimates between PHQ-8 and PHQ-9 among studies that used a semi-structured reference standard
| PHQ-8a | PHQ-9 | PHQ-8 – PHQ-9b | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cutoff | Sensitivity | 95% CI | Specificity | 95% CI | Sensitivity | 95% CI | Specificity | 95% CI | Sensitivity | 95% CI | Specificity | 95% CI |
| 5 | 0·98 | (0·95, 0·99) | 0·55 | (0·50, 0·60) | 0·98 | (0·95, 0·99) | 0·55 | (0·50, 0·60) | 0·00 | (−0·01, 0·00) | 0·00 | (0·00, 0·01) |
| 6 | 0·98 | (0·95, 0·99) | 0·63 | (0·58, 0·68) | 0·98 | (0·95, 0·99) | 0·63 | (0·58, 0·67) | 0·00 | (−0·00, 0·00) | 0·00 | (0·00, 0·01) |
| 7 | 0·97 | (0·93, 0·99) | 0·70 | (0·66, 0·74) | 0·98 | (0·93, 0·99) | 0·70 | (0·65, 0·74) | −0·01 | (−0·02, 0·00) | 0·00 | (0·00, 0·01) |
| 8 | 0·94 | (0·89, 0·96) | 0·76 | (0·72, 0·79) | 0·95 | (0·90, 0·97) | 0·75 | (0·71, 0·79) | −0·01 | (−0·03, 0·00) | 0·01 | (0·00, 0·01) |
| 9 | 0·89 | (0·84, 0·92) | 0·81 | (0·78, 0·84) | 0·91 | (0·87, 0·95) | 0·80 | (0·77, 0·83) | −0·02 | (−0·06, −0·00) | 0·01 | (0·00, 0·01) |
| 10b | 0·86 | (0·80, 0·90) | 0·86 | (0·83, 0·89) | 0·88 | (0·82, 0·92) | 0·86 | (0·82, 0·88) | −0·02 | (−0·06, −0·00) | 0·00 | (0·00, 0·02) |
| 11 | 0·81 | (0·75, 0·87) | 0·90 | (0·87, 0·92) | 0·84 | (0·84, 0·84) | 0·89 | (0·89, 0·89) | −0·03 | (−0·06, −0·00) | 0·01 | (0·00, 0·02) |
| 12 | 0·74 | (0·68, 0·79) | 0·92 | (0·89, 0·93) | 0·78 | (0·71, 0·83) | 0·91 | (0·89, 0·93) | −0·04 | (−0·09, −0·01) | 0·01 | (0·00, 0·01) |
| 13 | 0·67 | (0·60, 0·73) | 0·94 | (0·92, 0·95) | 0·69 | (0·63, 0·75) | 0·93 | (0·91, 0·95) | −0·02 | (−0·07, −0·00) | 0·01 | (0·00, 0·01) |
| 14 | 0·59 | (0·53, 0·65) | 0·96 | (0·94, 0·97) | 0·64 | (0·57, 0·70) | 0·95 | (0·93, 0·96) | −0·05 | (−0·09, −0·01) | 0·01 | (0·00, 0·01) |
| 15 | 0·51 | (0·44, 0·57) | 0·97 | (0·95, 0·98) | 0·55 | (0·48, 0·62) | 0·96 | (0·94, 0·97) | −0·04 | (−0·09, −0·02) | 0·01 | (0·00, 0·01) |
a
N Studies = 27; N Participants = 6,362; N major depression = 790
b
For PHQ-8 cutoff 10, among studies that used semi-structured interviews as the reference standard, the default optimizer in glmer failed to converge, thus bobyqa was used instead.
CI: confidence interval