Table 2. Prospective studies investigating the non-operative approach.

Study	No. of patients with complete response	Radiotherapy dose	Local control	% requiring salvage surgery	Overall survival
Habr-Gama et al., 2013 (59)	47	54 Gy	83% at 3 years	91%	94% at 3 years
Renehan et al., 2016 (60)	129	45 Gy/25#	62% at 3 years	88%	96% at 3 years
Appelt et al., 2015 (61)	40	60 Gy/30#	74% at 2 years	100%	100% at 2 years
Martens et al., 2016 (62)	61	NR	84.6% at 3 years	NR	96.6% at 3 years

NR, not reported.