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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: Immunity. 2019 Nov 12;51(6):1088–1101.e5. doi: 10.1016/j.immuni.2019.10.004

Figure 4. SHM in spleen and liver B cell blasts and PB.

Figure 4

(A) Mutation distribution in splenic and hepatic B cell blasts and PB populations. (B) Fraction of unmutated, GL-branched and trunk clones found in any of the 4 populations of hepatic and splenic B cell blasts and PB. (C-F) Fraction of clones shared within splenic and hepatic B cell blasts and PB populations of all clones (C), Unmutated clones (D), GL branched clones (E), and Trunk clones (F). (G) An example of a multi-tiered clonal lineage found in both spleen and liver. Nodes found in both organs are green, nodes found in spleen only are blue, nodes found in liver only are pink, inferred nodes are black. Node size is proportional to the number of sequences. *p <0.05, **p<0.01, ***p<0.001, ****p<0.0001 Statistics for A were done by two-way ANOVA. See figure S4.